veterinary textbook cover

CSU Clinical Trials Feature in New Veterinary Textbook

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Nutraceuticals in Veterinary Medicine covers ABSC Organics’ clinical trials at Colorado State University in Cannabis Chapter

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Image courtesy of Springer.

We’re delighted to see the CBD clinical safety and efficacy trials we’ve sponsored at CSU highlighted in the recently published Nutraceuticals in Veterinary Medicine textbook. With over sixty chapters covering supplements and their use in animals, this textbook from Springer is a comprehensive resource for veterinarians and researchers. Chapter 10—entitled “Cannabis in Veterinary Medicine: Cannabinoid Therapies for Animals—delves deep in the science and research around veterinary use of cannabis and CBD. 

Comprehensive Treatment of Veterinary CBD Use

The chapter covers everything from the history of veterinary cannabis use and regulatory and legal considerations to a deep dive into the chemistry of the cannabis plant and the pharmacology of cannabinoids such as cannabidiol (CBD). Highlighted topics include:

  • The 2018 Farm Bill and its effects on industry and research
  • Detailed look at the endocannabinoid system (including a terrific graphic illustrating the feedback loop for the endocannabinoid signaling system)
  • Nutritional value of Cannabis/Hemp seed oil – Fatty acid profile has anti-inflammatory properties
  • Review of the endocannabinoid system (ECS) in humans – including beneficial effects for sleep, anxiety and stress, obesity and metabolic disorders, cancer, and inflammatory conditions
  • Review of the ECS in animals – focuses on dogs but touches on all mammals, birds, fish, and even invertebrates
  • Phytocannabinoids, terpenes, and the Entourage effect (importance of full spectrum CBD product to achieve synergistic benefits from all compounds)
  • Good manufacturing processes and the importance of organic hemp
  • The importance of third party lab testing for potency and contamination
  • Completed and ongoing clinical trials at Colorado State University and Cornell

Clinical Trials at CSU Featured

Dr. Stepahnie McGrath and Saint Bernard enrolled in CBD Safety Trial at CSU
Dr. Stephanie McGrath and Breonna Thomas, clinical trials coordinator at Colorado State University’s Veterinary Teaching Hospital with Atticus, a Saint Bernard enrolled in a clinical trial of cannabidiol for the treatment of epilepsy, (Photo by John Eisele/Colorado State University Photography)

Beginning on page 140 (Section 6) the authors cover the Colorado State University clinical trials in impressive detail. They discuss everything from the Phase One safety study to the efficacy studies for epilepsy and osteoarthritis. We are thrilled to see everything we are learning with Dr. McGrath and her team at CSU consolidated in a textbook that will inform veterinarians for years to come. 

Cannabis Chapter Available on FDA Website

Currently, you can view the entire Cannabis chapter on the FDA’s website here. The authors submitted the paper as part of the public comment process for the FDA’s Proposed Rule: Scientific Data and Information About Products Containing Cannabis or Cannabis-Derived Compounds; Public Hearing; Request for Comments. 

Every time our research is published, we advance the CBD knowledge bar a little further. Our goal is to keep researching CBD to provide optimized dosing recommendations and determine even more applications for the powerful supplement. As we keep learning, we’ll keep sharing the news and knowledge with you here on our blog, so stay tuned! 

Need to purchase ABSC Pure Organic CBD Oil™ for your pet? Shop now!

News

CSU Epilepsy Study Results Published!

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“Promising” Epilepsy Trial Results Published in June 1 Issue of the Journal of the American Veterinary Association

We first reported on the encouraging preliminary results of Dr. Stephanie McGrath’s epilepsy trial last year. Now, the complete results of this groundbreaking pilot study have been published in the Journal of the American Veterinary Association’s June 1 issue. If you’ve got a pet with epilepsy, you’re going to want to pay attention to this study!

Clinical Trial Backs Up Anecdotal Evidence

We’ve been hearing from customers for years that our Pure Organic CBD Oil helps reduce the severity, frequency, and duration of seizures in their epileptic pets. We get thank you notes, rave reviews, and even videos that show the beneficial effects of our product. Now, we’re starting to see the fruits of our research in the form of clinical trial results.

Pilot Study Shows Significant Reduction in Seizures with CBD Treatment

Twenty six dogs with intractable idiopathic epilepsy were initially enrolled in the pilot study. After exclusions, sixteen dogs completed the 12-week trial. In this double blind study, the dogs were randomly assigned to a CBD group or placebo group. The CBD group received ABSC’s CBD-infused oil twice daily for 12 weeks while continuing their existing antiepileptic treatments. The placebo group received oil without CBD, and also continued their existing medications. All other parameters were consistent for both groups. Dr. McGrath and her colleagues at CSU compared seizure activity, adverse effects, and plasma CBD concentrations over the course of the twelve weeks, and found that 89% of the dogs in the CBD group saw a reduction in seizure frequency. Researchers also found a strong correlation between plasma (blood) CBD concentration and seizure frequency. Further studies will evaluate whether higher doses of CBD decrease seizure activity even further.

These results are groundbreaking when it comes to veterinary CBD usage, and they are generating lots of buzz in the veterinary community and beyond. Check out Dr. McGrath–and a nice closeup of our product (old label)–on the news in Denver:

More CBD Trials to Come

Based on the exciting results from this pilot study, Dr. McGrath is currently working on a larger epilepsy study supported by the AKC Canine Health Foundation. Stay tuned for more promising results, and visit the AKC Canine Health Foundation site to learn how you can help with their research initiatives. In the meantime you can purchase the very same CBD product used in Dr. McGrath’s study for your pet here at petpainfree.com. Whether your pet suffers from epilepsy, arthritis, inflammation, anxiety, or another disorder, ABSC Pure Organic CBD Oil may be able to provide relief.

ABSC Organics Cares Enough to Do the Research

At ABSC Organics, we put our money where our mouth is. We partner with some of the world’s best veterinary researchers because we believe in our product and in the power of CBD. Want to learn more about past, current, and future clinical trials with ABSC Pure Organic CBD Oil? Check out our Clinical Trial page for more info!

Dr. Stephanie McGrath

Dr. Stephanie McGrath Addresses CSU Pueblo

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Assessment of Safety, Toxicity, and Pharmacokinetics of Cannabidiol in Healthy Dogs

Have you ever wanted to know more about ABSC and how we came to be involved with clinical trials at CSU? We’re pulling a video out of the archives today to share with you! This short video of Veterinary Neurologist Dr. Stephanie McGrath speaking at a conference at CSU Pueblo in 2017 highlights her work on safety, toxicity, and pharmacokinetics of CBD. During her talk, Dr. McGrath discusses her interest in testing CBD for dogs and her concerns with unregulated and untested CBD products. She needed a safe and pure product to run trials with, and ABSC wanted to support advanced research in the field. It was a match made in heaven, and the rest is history!

Webinar update on CBD oil for pets

AKCCHF Update on the Science Behind CBD For Pets

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Learn from Stephanie McGrath, DVM, in the latest installment of  the VetVine – AKC Canine Health Foundation Canine Health Bytes education series

Our favorite veterinarian and Board Certified specialist in Neurology went live on VetVine last week! Dr. Stephanie McGrath is one of the nation’s leading experts in the field of veterinary CBD clinical research, and she has conducted several clinical trials with our Pure Organic CBD oil. In partnership with the AKC’s Canine Health Foundation and VetVine, she presented a timely update on the science behind veterinary CBD use.

Dr. McGrath’s webinar is packed with valuable information for veterinarians and pet owners. If you missed it, don’t despair – you can still register with VetVine at no cost and view the webinar on demand!

In this one hour presentation, Dr. McGrath covers many important topics related to veterinary CBD use:

  • Legal hurdles facing veterinarians and researchers – did you know that your vet can’t discuss CBD options unless you bring it up first?
  • Clinical trials that have already been completed at Colorado State University and Cornell – epilepsy and osteoarthritis studies have shown promising results.
  • Ongoing and prospective clinical trials – it’s not too late to sign up!
  • AKC-sponsored trials at CSU use ABSC Pure Organic CBD Oil™
  • Best delivery methods – oil beats capsules and topical creams
  • Clinical and anecdotal evidence for efficacy and safety
  • Concerns about lack of industry regulation – are you buying what you think you’re buying?
  • Questions about dosing and contraindications

ABSC is proud to supply and fund Dr. McGrath’s research

Applied Basic Science is proud to partner with Dr. McGrath to supply the funding and the CBD oil for her clinical trials at CSU. Together with Dr. McGrath and her colleagues, we believe that knowledge is power. The more we learn about CBD’s benefits, the more we want to know. To that end, we continue to work with Dr. McGrath and researchers around the world to more fully understand CBD’s beneficial effects.

Applied Basic Science–it’s our name for a reason!

Dr. McGrath’s scientific protocols inform ABSC’s science-based approach to veterinary CBD use every day. Each batch is tested by a third-party laboratory, and every bottle that leaves our facility has passed a rigorous screening process. So when you buy ABSC Pure Organic CBD Oil™, you can count on a consistent CBD profile, guaranteed low THC levels (always less than 0.3%), and zero contaminants.

We’re grateful to Dr. McGrath, the Canine Health Foundation, and VetVine for providing this terrific educational resource. Want more? Peruse our News and Research Archive, or visit our YouTube Channel for more educational video content. Together, we’re learning more about CBD’s amazing benefits every day. Stay tuned!

Applied Basic Science Shines at 20th Annual CVMBS Research Day

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Research students at Colorado State University – working with CBD oil supplied by Applied Basic Science – garnered third place accolades at the 20th Annual CVMBS Research Day on Saturday. This informative poster details a current canine epilepsy study conducted by Dr. Stephanie McGrath at CSU. Dr. McGrath and her team are working in conjunction with Applied Basic Science and the American Kennel Club – Canine Health Foundation. Their current study tests the following hypothesis: CBD will be a safe and effective therapy for uncontrolled canine epilepsy with minimal adverse side effects. Promising preliminary results are encouraging. Researchers note that “CBD has the potential to reduce seizure frequency in dogs with uncontrolled, idiopathic epilepsy.”

CBD Oil provided by Applied Basic Science shows promising results with canine epilepsy patients.
CBD research

Clinical Testing Defines Applied Basic Science

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CBD—the non-psychoactive derivative of the marijuana and hemp plants—has taken off among humans, marketed as a solution for everything from pain and anxiety to skin care and diet.

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CBD Safetly Trial CSU

Groundbreaking Safety, Toxicity, and Pharmacokinetics Study Published

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ABSC Sponsored Safety Study Published in the  Journal of the American Holistic Veterinary Medical Association

We are thrilled to announce that our Phase 1 Clinical Trial: Assessment of Safety, Toxicity, and Pharmacokinetics of Cannabidiol in Healthy Dogs has been successfully completed. Sponsored by ABSC Organics and conducted at Colorado State University’s College of Veterinary Medicine and Biomedical Sciences, the trial studied three different delivery mechanisms in 30 healthy beagles. With results appearing in the Fall 2018 issue of the Journal of the American Holistic Veterinary Medical Association, the study concluded that clinical doses of CBD were well tolerated by all the dogs in the study. This is groundbreaking news in the veterinary field, and represents a major step forward for CBD research and pet wellness.

St. Bernard in CBD Clinical Trial
Dr. Stephanie McGrath with Atticus, a 3-year-old Saint Bernard enrolled in a clinical trial of cannabidiol at Colorado State University’s Veterinary Teaching Hospital (Photo by John Eisele/Colorado State University Photography)

ABSC Organics–The Only Veterinary CBD Company With a Phase 1 Safety Trial

At ABSC we know that it’s easy to make claims, but more important to invest in the research to back up those claims. We care deeply about pets and their well-being. That’s why we’re so proud of the fact that ABSC Pure Organic CBD Oil is the only veterinary CBD product that has undergone a Phase 1 trial to assess safety and toxicity. This trial enables researchers to use our product in Phase 2 trials that will study CBD’s effects on epilepsy, arthritis, and more.

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Two Clinical Studies: Osteoarthritis and Epilepsy

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ABSC Pure Organic CBD Oil™ For Dogs Used in More Clinical Trials

Aided in large part by the commitment and investment of science-driven firms like ABSC Organics, cannabis research for veterinary patients is cautiously advancing. Dr. Stephanie McGrath, a neurologist and assistant professor at Colorado State University’s College of Veterinary Medicine & Biomedical Sciences, is on the forefront of veterinary cannabidiol research. She has completed two recent clinical studies on the effects of cannabidiol in dogs with epilepsy or osteoarthritis. This work was recently published in The Journal of the American Veterinary Association:

“An initial investigation involving 30 healthy research animals found that CBD was tolerated and resulted in measurable blood concentrations. Dr. McGrath expects results of that study will be published this year. Data from the other studies are being analyzed, but preliminary results of the epilepsy investigation were promising enough that, in January, Dr. McGrath began a three-year crossover study of CBD for epilepsy in dogs with a $350,000 grant from the American Kennel Club.”

ABSC Organics is a Proud Partner in Advancing the Field of Veterinary CBD Research

ABSC Organics provided the funding and CBD oil for Dr. McGrath’s study. We are deeply committed to raising the bar for research and analysis in this arena, and we are proud to partner with the scientists who are leading the push for better data and rigorous clinical analysis.

For the full text of the JAVMA article, click here, or visit our News and Research page for news and updates on other ongoing clinical studies.